ECOFECT > Presentation > Teams

Autophagy Infection Immunity

Inserm U1111 - UMR CNRS 5308

Address : 
International Center for Infectiology Research (CIRI)
Email : 
mathias.faure@Inserm.fr
Trusteeship : 
Inserm, CNRS , ENS Lyon, UCBL,

Organization

Team leader: Mathias Faure

Axe(s) of research

Macroautophagy, usually referred to as autophagy is a highly conserved, self-degradative vesicular pathway for clearance and recycling of cellular cytoplasmic contents by the lysosome. Autophagy also plays an essential role in cellular immunity, as it can entrapped and degrade intracellular pathogens, what can lead to the activation of innate and adaptive immune responses against microorganisms. However, co-evolution between host-cells and pathogens has selected numerous infectious invading microorganisms able to avoid or usurp autophagy to their own benefit. Our team is interested by understanding mechanisms underlying the anti-microbial properties of autophagy, as well as those used by certain pathogens to escape from or exploit this cellular process.

Key words: Immunology, Host-pathogen interaction, Autophagy, Immunity, Measles virus

Domains

Immunology
Host-pathogen interaction

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